Across TCGA patient cohorts, DEFB116 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB116-associated genes across cancer lineages are BTF3P15, NICN2P, and DUXAP3. Each is linked with DEFB116 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB116-to-partner and partner-to-DEFB116 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB116→partner) and Y-score (partner→DEFB116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BTF3P15 →	+0.286	+5.516	<.001	.004	3	2
SKCM	NICN2P →	+0.060	+2.855	.001	.009	3	2
SKCM	DUXAP3 →	+0.081	+3.555	<.001	.004	3	2
SKCM	RN7SL210P →	+0.093	+3.625	<.001	.004	3	1
SKCM	MIR6077 →	+0.341	+3.110	<.001	.005	3	1
COAD	MIR31 →	+0.718	+6.547	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

Exploration

DEFB116 survival (RNA) · tumor vs normal (RNA) · all DEFB116 data types