Across TCGA cell cohorts, DEFB116 RNA expression is significantly associated with the mutation status of many other genes, with 14 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DEFB116-associated genes across cancer lineages are PIAS4, WSCD1, and CTR9. Each is linked with DEFB116 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB116-to-partner and partner-to-DEFB116 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB116→partner) and Y-score (partner→DEFB116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PIAS4 →	+4.643	+0.230	.008	<.001	3	1
LUNG_NSCLC_LUSC	WSCD1 →	+4.643	+0.230	.008	<.001	3	1
LUNG_NSCLC_LUSC	CTR9 →	+4.643	+0.230	.008	<.001	3	1
LUNG_NSCLC_LUSC	PAG1 →	+4.643	+0.230	.008	<.001	3	1
LUNG_NSCLC_LUSC	N4BP2 →	+4.643	+0.230	.008	<.001	3	1
OVARY	ANO1 →	+5.807	+0.126	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

DEFB116 survival (RNA) · tumor vs normal (RNA) · all DEFB116 data types