Across TCGA patient cohorts, DEFB115 mutation is significantly associated with the RNA expression of many other genes, with 274 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB115-associated genes across cancer lineages are RPS29P32, TSPY6P, and RNU6-841P. Each is linked with DEFB115 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB115-to-partner and partner-to-DEFB115 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB115→partner) and Y-score (partner→DEFB115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS29P32 →	+1.422	+5.184	<.001	.001	3	2
LUAD	TSPY6P →	+0.537	+5.087	<.001	.004	3	2
UCEC	RNU6-841P →	+0.674	+4.694	<.001	.007	3	2
SKCM	OR5B15P →	+0.013	+4.110	<.001	.005	3	2
SKCM	CYCSP29 →	+0.056	+2.638	<.001	.006	3	2
SKCM	TSPY7P →	+0.040	+4.110	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 274 associations by consensus.

Exploration

DEFB115 survival (RNA) · tumor vs normal (RNA) · all DEFB115 data types