Across TCGA pan-cancer cohorts, DEFB115 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated DEFB115 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DEFB115 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB115 expression acts as an unfavorable survival marker.

HNSC, KIRC, and LIHC are the cancer types where DEFB115 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.175	0.631	<.001	162	view →
KIRC	OS	Tertile	II,III,IV	0.419	0.814	.001	117	view →
LIHC	OS	Tertile	All	0.079	0.774	<.001	72	view →
PAAD	OS	Tertile	All	0.117	0.613	<.001	63	view →
KIRP	DFS	Tertile	II,III,IV	0.038	0.771	<.001	60	view →
SKCM	DFS	Tertile	III,IV	0.054	0.656	<.001	45	view →
OV	OS	Tertile	IV	0.296	0.772	.003	36	view →
ESCA	OS	Tertile	II,III,IV	0.249	0.568	<.001	27	view →
SARC	DFS	Tertile	All	0.075	0.636	<.001	21	view →
LAML	DFS	Tertile	All	0.028	0.583	.001	18	view →
ACC	DFS	Tertile	II,III,IV	0.048	0.581	<.001	18	view →
PRAD	OS	Tertile	All	0.826	0.990	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

Exploration

Same gene, other analysis: DEFB115 tumor-vs-normal RNA expression · all DEFB115 data types