Across TCGA patient cohorts, DEFB115 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFB115-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, mTOR_pS2448, and cIAP. Each is linked with DEFB115 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB115-to-partner and partner-to-DEFB115 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB115→partner) and Y-score (partner→DEFB115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.871	+3.321	.002	.010	3	1
SKCM	mTOR_pS2448 →	-0.220	-3.321	.019	.010	3	1
SKCM	cIAP →	+0.157	+2.833	.040	.034	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

DEFB115 survival (RNA) · tumor vs normal (RNA) · all DEFB115 data types