DEFB109A

Across TCGA patient cohorts, DEFB109A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB109A-associated genes across cancer lineages are ELOCP5, ANKRD36P1, and SNORD115-34. Each is linked with DEFB109A in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB109A-to-partner and partner-to-DEFB109A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOCP5 grouped by DEFB109A-low versus DEFB109A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB109A→partner) and Y-score (partner→DEFB109A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELOCP5 →	+0.113	+8.066	<.001	.007	3	1
UCEC	ANKRD36P1 →	+0.059	+8.066	<.001	.007	3	1
UCEC	SNORD115-34 →	+0.378	+8.066	<.001	.007	3	1
UCEC	ZNF736P7Y →	+0.049	+8.066	<.001	.007	3	1
UCEC	OR5BN2P →	+0.064	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ELOCP5 by DEFB109A expression — UCEC

Explore this box plot interactively →