DEFB109A

Across TCGA pan-cancer cohorts, DEFB109A RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated DEFB109A data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher DEFB109A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFB109A expression acts as an unfavorable survival marker, although some lineages such as LGG and ACC show a favorable association.

CESC, STAD, and LGG are the cancer types where DEFB109A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	All	0.377	0.580	.007	36	view →
STAD	OS	Quartile	All	0.596	0.794	.012	30	view →
LGG	OS	Median	All	0.940	0.832	.002	27	view →
KIRP	DFS	Quartile	II,III,IV	0.193	0.869	.003	25	view →
ACC	DFS	Tertile	All	0.812	0.378	.025	25	view →
ESCA	DFS	Quartile	All	0.337	0.577	.003	18	view →
THYM	OS	Quartile	All	0.672	0.981	.003	15	view →
LUAD	DFS	Median	All	0.232	0.427	.015	14	view →
COAD	DFS	Tertile	III,IV	0.417	0.597	.020	12	view →
KIRC	DFS	Median	III,IV	0.737	0.524	.005	10	view →
SKCM	DFS	Median	All	0.676	0.757	.024	8	view →
BRCA	OS	Median	All	0.975	0.949	.014	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

DEFB109A–CESC (DFS)

Open the CESC breakdown →