Across TCGA patient cohorts, DEFB108B mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFB108B-associated genes across cancer lineages are OR4K15, RNU6-249P, and RNU6-792P. Each is linked with DEFB108B in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB108B-to-partner and partner-to-DEFB108B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB108B→partner) and Y-score (partner→DEFB108B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR4K15 →	+0.141	+4.937	<.001	.005	3	1
UCEC	RNU6-249P →	+0.714	+5.109	<.001	.001	3	1
UCEC	RNU6-792P →	+0.447	+5.722	<.001	.001	3	1
UCEC	IGHD5-12 →	+0.915	+5.123	<.001	.004	3	1
UCEC	SERPINB8P1 →	+0.388	+4.551	<.001	.009	3	1
UCEC	BMS1P11 →	+0.145	+4.606	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

DEFB108B survival (RNA) · tumor vs normal (RNA) · all DEFB108B data types