Across TCGA pan-cancer cohorts, DEFB108B RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DEFB108B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DEFB108B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEFB108B is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where DEFB108B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFB108B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+0.045	.013	8	view →
THCA	All	II,III,IV	−0.093	.003	6	view →
LUSC	All	All	+0.029	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DEFB108B RNA expression & survival · all DEFB108B data types