Across TCGA pan-cancer cohorts, DEFB105B RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated DEFB105B data layer.
The strongest signal is observed in uterine carcinosarcoma (UCS), where higher DEFB105B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB105B expression acts as an unfavorable survival marker.
UCS, DLBC, and ACC are the cancer types where DEFB105B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.