Q-omics provides the consensus-scored DEFB105B profile across patient tissues and cancer cell-line models. DEFB105B expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in UCS. Additionally, DEFB105B RNA expression shows 1,350 significant gene co-expression associations, with the highest sampling consensus in KIRC. Together, these results highlight UCS, and KIRC as cancer lineages where DEFB105B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes DEFB105B survival associations across molecular data types. DEFB105B RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DEFB105B data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	7	UCS (108)	view →

This table ranks reproducible DEFB105B RNA expression–survival associations across cancer types. High DEFB105B expression shows unfavorable associations in UCS, DLBC, ACC, KIRC, GBM and ESCA. The UCS Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCS as the clearest survival context for DEFB105B RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.104	0.688	<.001	108	view →
DLBC	OS	Tertile	II,III,IV	0.172	0.949	<.001	81	view →
ACC	OS	Tertile	All	0.114	0.892	<.001	72	view →
KIRC	DFS	Tertile	II,III,IV	0.167	0.760	<.001	54	view →
GBM	OS	Tertile	All	0.069	0.415	<.001	27	view →
ESCA	DFS	Tertile	III,IV	0.162	0.447	.021	18	view →

Pink = unfavorable, green = favorable. all 7 lineages →

DEFB105B-UCS (OS)

Kaplan–Meier survival curve for DEFB105B RNA expression in UCS: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with DEFB105B in patient tissues and cancer cell lines. In patient samples, DEFB105B shows the broadest associations at the RNA and protein expression levels, with KIRC recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	1,350	KIRC (1043)	view →
Function (RNA)	132	KIRC (82)	view →