Across TCGA cell cohorts, DEFB105A RNA expression is significantly associated with the mutation status of many other genes, with 16 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DEFB105A-associated genes across cancer lineages are SPG11, PHF14, and ATG2A. Each is linked with DEFB105A in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFB105A-to-partner and partner-to-DEFB105A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFB105A→partner) and Y-score (partner→DEFB105A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPG11 →	+4.058	+0.120	.007	<.001	3	1
LUNG_SCLC	PHF14 →	+4.643	+0.150	.004	<.001	3	1
LUNG_SCLC	ATG2A →	+4.643	+0.150	.004	<.001	3	1
LUNG_SCLC	LARS2 →	+4.643	+0.150	.004	<.001	3	1
LUNG_SCLC	DPP6 →	+4.058	+0.120	.007	<.001	3	1
LUNG_SCLC	SLC14A2 →	+4.058	+0.120	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

DEFB105A survival (RNA) · tumor vs normal (RNA) · all DEFB105A data types