Q-omics provides the consensus-scored DEFB103B profile across patient tissues and cancer cell-line models. DEFB103B expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in HNSC. Additionally, DEFB103B RNA expression shows 5,085 significant gene co-expression associations, with the highest sampling consensus in HNSC. Together, these results highlight HNSC as cancer lineages where DEFB103B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes DEFB103B survival associations across molecular data types. DEFB103B RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DEFB103B data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	7	HNSC (63)	view →

This table ranks reproducible DEFB103B RNA expression–survival associations across cancer types. High DEFB103B expression shows unfavorable associations in LUSC, KIRC, OV and LIHC, but favorable associations in HNSC and ESCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for DEFB103B RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.817	0.485	<.001	63	view →
LUSC	OS	Tertile	All	0.068	0.825	<.001	54	view →
KIRC	DFS	Tertile	II,III,IV	0.167	0.670	<.001	54	view →
ESCA	OS	Tertile	IV	0.743	0.290	.013	36	view →
OV	OS	Tertile	IV	0.254	0.634	.028	18	view →
LIHC	DFS	Tertile	III,IV	0.040	0.361	<.001	18	view →

Pink = unfavorable, green = favorable. all 7 lineages →

DEFB103B-HNSC (OS)

Kaplan–Meier survival curve for DEFB103B RNA expression in HNSC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with DEFB103B in patient tissues and cancer cell lines. In patient samples, DEFB103B shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, DEFB103B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	5,085	HNSC (2578)	view →
Function (RNA)	3,721	HNSC (3278)	view →

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	696	BONE (204)	view →
shRNA	216	LARGE_INTESTINE (67)	view →