DEFA9P

Across TCGA patient cohorts, DEFA9P RNA expression is significantly associated with the go_rna of many other GO terms, with 5,367 significant associations in total. ESCA shows the largest number of these associations.

The most reproducible DEFA9P-associated GO terms across cancer lineages are Positive regulation of DNA recombination, Positive regulation of double-strand break repair via homologous recombination, and Mitochondrial genome maintenance. Each is linked with DEFA9P in more than 9 cancer types. Because this analysis shows association rather than direction, both DEFA9P-to-partner and partner-to-DEFA9P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA recombination grouped by DEFA9P-low versus DEFA9P-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA9P→partner) and Y-score (partner→DEFA9P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of DNA recombination →	+0.082	+0.114	<.001	.003	3	9
ESCA	Positive regulation of double-strand break repair via homologous recombination →	+0.091	+0.187	<.001	.004	2	10
ESCA	Mitochondrial genome maintenance →	+0.086	+0.140	<.001	<.001	3	8
ESCA	Positive regulation of DNA repair →	+0.091	+0.144	<.001	<.001	3	8
ESCA	Negative regulation of gene expression, epigenetic →	+0.098	+0.201	<.001	<.001	3	8
ESCA	Positive regulation of DNA metabolic process →	+0.096	+0.165	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,367 associations by consensus.

Positive regulation of DNA recombination by DEFA9P expression — ESCA

Explore this box plot interactively →