DEFA6

Across TCGA pan-cancer cohorts, DEFA6 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated DEFA6 data layer compared with 17 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DEFA6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DEFA6 expression acts as an unfavorable survival marker.

LUAD and LUSC are the cancer types where DEFA6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.083	0.788	<.001	30	view →
LUSC	OS	Median	II,III,IV	0.172	0.742	.006	24	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

DEFA6–LUAD (OS)

Open the LUAD breakdown →