DEFA6

Across TCGA pan-cancer cohorts, DEFA6 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DEFA6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DEFA6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEFA6 is over-expressed in tumor, although a few such as STAD and LUAD show the opposite, repressed pattern.

COAD, STAD, and LUAD are the cancer types where DEFA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+2.183	<.001	9	view →
STAD	Male	All	−3.302	.008	4	view →
LUAD	All	III,IV	−0.090	.008	4	view →
READ	All	All	+3.620	.005	2	view →
HNSC	Male	III,IV	+0.120	.016	2	view →
LIHC	All	II,III,IV	+0.097	.028	2	view →
LUSC	Female	II,III,IV	−0.124	.030	1	view →
KIRP	All	III,IV	+0.062	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

DEFA6–COAD

Open the COAD breakdown →