DEFA6

Across TCGA pan-cancer cohorts, DEFA6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DEFA6 data layer compared with 17 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DEFA6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFA6 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where DEFA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.817	1.000	.017	12	view →
PDAC	DFS	Median	II,III,IV	0.521	0.309	.006	9	view →
UCEC	DFS	Median	II,III,IV	0.253	1.000	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DEFA6–COAD (DFS)

Open the COAD breakdown →