DEFA6

Across TCGA patient cohorts, DEFA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,117 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible DEFA6-associated GO terms across cancer lineages are Disruption of plasma membrane integrity in another organism, Disruption of cellular anatomical structure in another organism, and Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Each is linked with DEFA6 in more than 18 cancer types. Because this analysis shows association rather than direction, both DEFA6-to-partner and partner-to-DEFA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Disruption of plasma membrane integrity in another organism grouped by DEFA6-low versus DEFA6-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA6→partner) and Y-score (partner→DEFA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Disruption of plasma membrane integrity in another organism →	+1.308	+2.244	<.001	<.001	3	19
KICH	Disruption of cellular anatomical structure in another organism →	+0.913	+0.111	.001	<.001	2	11
ESCA	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.042	+1.266	.002	<.001	3	6
THYM	Establishment of mitotic spindle localization →	+0.065	+2.813	<.001	<.001	3	6
THYM	Regulation of chromosome organization →	+0.060	+3.173	<.001	<.001	3	6
STAD	Regulation of epidermis development →	+0.029	+0.866	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,117 associations by consensus.

Disruption of plasma membrane integrity in another organism by DEFA6 expression — STAD

Explore this box plot interactively →