DEFA6

Across TCGA patient cohorts, DEFA6 mutation is significantly associated with the RNA expression of many other genes, with 262 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFA6-associated genes across cancer lineages are NOC2L, HMGN2P21, and RNA5SP411. Each is linked with DEFA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA6-to-partner and partner-to-DEFA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOC2L grouped by DEFA6-low versus DEFA6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA6→partner) and Y-score (partner→DEFA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NOC2L →	+0.534	+3.591	.004	.001	3	2
SKCM	HMGN2P21 →	+0.272	+3.750	.004	.001	3	2
UCEC	RNA5SP411 →	+1.401	+3.130	.001	.003	3	1
BLCA	PSMB7P1 →	+0.104	+7.640	<.001	.009	3	1
LUAD	MRPL57P6 →	+0.199	+7.930	<.001	.008	3	1
SKCM	LINC00701 →	+0.143	+2.821	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 262 associations by consensus.

NOC2L by DEFA6 expression — SKCM

Explore this box plot interactively →