DEFA6

Across TCGA patient cohorts, DEFA6 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEFA6-associated genes across cancer lineages are Mast cells and MEP. Each is linked with DEFA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA6-to-partner and partner-to-DEFA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mast cells grouped by DEFA6-low versus DEFA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA6→partner) and Y-score (partner→DEFA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Mast cells →	+0.024	+2.850	.012	.035	3	1
UCEC	MEP →	+0.038	+2.818	.023	.037	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Mast cells by DEFA6 expression — UCEC

Explore this box plot interactively →