DEFA6

Across TCGA cell cohorts, DEFA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 476 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEFA6-associated GO terms across cancer lineages are Disruption of cellular anatomical structure in another organism, Disruption of plasma membrane integrity in another organism, and Positive regulation of coagulation. Each is linked with DEFA6 in more than 5 cancer types. Because this analysis shows association rather than direction, both DEFA6-to-partner and partner-to-DEFA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Disruption of cellular anatomical structure in another organism grouped by DEFA6-low versus DEFA6-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA6→partner) and Y-score (partner→DEFA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Disruption of cellular anatomical structure in another organism →	+1.143	+1.802	<.001	<.001	3	6
LARGE_INTESTINE	Disruption of plasma membrane integrity in another organism →	+1.143	+1.802	<.001	<.001	3	6
BLOOD_Lymphoma	Positive regulation of coagulation →	-0.115	-0.070	<.001	.002	3	4
BLOOD_Lymphoma	Positive regulation of hemostasis →	-0.113	-0.070	.001	.002	3	3
BLOOD_Lymphoma	Positive regulation of blood coagulation →	-0.113	-0.070	.001	.002	3	3
BLOOD_Lymphoma	tRNA methylation →	+0.047	+0.048	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 476 associations by consensus.

Disruption of cellular anatomical structure in another organism by DEFA6 expression — LARGE_INTESTINE

Explore this box plot interactively →