DEFA3

Across TCGA pan-cancer cohorts, DEFA3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DEFA3 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DEFA3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFA3 expression acts as an unfavorable survival marker.

CCRCC, COAD, and HNSC are the cancer types where DEFA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.562	0.904	<.001	52	view →
COAD	DFS	Quartile	II,III,IV	0.818	1.000	.026	30	view →
HNSC	DFS	Median	III,IV	0.906	1.000	.006	5	view →
LUAD	OS	Tertile	All	0.678	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DEFA3–CCRCC (DFS)

Open the CCRCC breakdown →