DEFA3

Across TCGA pan-cancer cohorts, DEFA3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DEFA3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DEFA3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DEFA3 is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where DEFA3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFA3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.830	<.001	11	view →
COAD	Female	II,III,IV	+1.144	<.001	9	view →
LUAD	All	All	−0.661	.001	5	view →
PDAC	Female	All	+1.590	.002	4	view →
CCRCC	All	All	−0.880	<.001	4	view →
LSCC	All	III,IV	+1.305	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DEFA3–HNSC

Open the HNSC breakdown →