DEFA10P

Across TCGA pan-cancer cohorts, DEFA10P RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated DEFA10P data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher DEFA10P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFA10P expression acts as an unfavorable survival marker, although some lineages such as THYM and SARC show a favorable association.

STAD, CESC, and READ are the cancer types where DEFA10P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	II,III,IV	0.229	0.545	.004	36	view →
CESC	OS	Tertile	All	0.146	0.599	.003	36	view →
READ	OS	Tertile	III,IV	0.334	0.752	.009	36	view →
GBM	OS	Tertile	All	0.005	0.416	<.001	36	view →
LGG	OS	Tertile	All	0.412	0.850	<.001	30	view →
THYM	OS	Tertile	II,III,IV	0.922	0.515	.001	19	view →
PAAD	OS	Tertile	II,III,IV	0.179	0.632	<.001	18	view →
LIHC	DFS	Tertile	II,III,IV	0.137	0.439	<.001	9	view →
CHOL	DFS	Tertile	All	0.129	0.544	.042	6	view →
PRAD	OS	Tertile	All	0.942	0.996	.046	6	view →
SARC	DFS	Tertile	All	0.543	0.307	.025	3	view →
LUSC	DFS	Tertile	All	0.199	0.395	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

DEFA10P–STAD (DFS)

Open the STAD breakdown →