DEFA10P

Across TCGA pan-cancer cohorts, DEFA10P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DEFA10P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where DEFA10P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEFA10P is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.

KIRP, BRCA, and HNSC are the cancer types where DEFA10P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEFA10P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.157	.028	4	view →
BRCA	All	All	−0.019	.018	4	view →
HNSC	Male	II,III,IV	−0.034	.041	2	view →
LIHC	All	All	+0.052	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DEFA10P–KIRP

Open the KIRP breakdown →