Across TCGA patient cohorts, DEFA1 RNA expression is significantly associated with the mutation status of many other genes, with 32 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible DEFA1-associated genes across cancer lineages are IGSF1, WDFY3, and UVSSA. Each is linked with DEFA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA1-to-partner and partner-to-DEFA1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA1→partner) and Y-score (partner→DEFA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	IGSF1 →	+4.029	+0.010	.005	<.001	3	1
STAD	WDFY3 →	+3.667	+0.010	.009	<.001	3	1
STAD	UVSSA →	+6.837	+0.044	<.001	<.001	3	1
STAD	PCDHGA4 →	+3.667	+0.010	.009	<.001	3	1
LUSC	GCAT →	+7.924	+0.064	.008	<.001	3	1
LUSC	NMRK1 →	+7.924	+0.064	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

DEFA1 survival (RNA) · tumor vs normal (RNA) · all DEFA1 data types