Across TCGA pan-cancer cohorts, DEFA1 RNA is linked to patient survival in 2 of 34 cancer types, making it the most broadly survival-associated DEFA1 data layer.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher DEFA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEFA1 expression acts as an unfavorable survival marker.

PRAD and GBM are the cancer types where DEFA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Tertile	All	0.111	0.886	<.001	24	view →
GBM	OS	Tertile	All	0.121	0.415	.042	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: DEFA1 tumor-vs-normal RNA expression · all DEFA1 data types