DEF6

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DEF6 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,284 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DEF6-associated proteins across cancer lineages are ANKRD44, LCP1, and LCP2. Each is linked with DEF6 in more than 8 cancer types. Because this analysis shows association rather than direction, both DEF6-to-partner and partner-to-DEF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEF6 versus ANKRD44 in OV, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF6→partner) and Y-score (partner→DEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVANKRD44 →+0.630+0.846<.001<.00139
GBMLCP1 →+0.932+0.933<.001<.00139
GBMLCP2 →+0.637+0.914<.001<.00139
GBMLSP1 →+0.771+0.824<.001<.00139
GBMARHGAP45 →+0.720+0.870<.001<.00139
GBMWAS →+0.800+1.048<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 16,284 associations by consensus.

DEF6 vs ANKRD44 — OV

Per-sample scatter of DEF6 vs ANKRD44 in OV (Pearson r = 0.51).

Explore this scatter interactively →

Exploration