DDX60

Across TCGA pan-cancer cohorts, DDX60 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX60 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DDX60 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DDX60 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where DDX60 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	1.000	0.906	.006	40	view →
LUAD	DFS	Tertile	III,IV	0.854	0.215	.002	20	view →
PDAC	OS	Median	IV	0.231	0.927	.004	6	view →
UCEC	DFS	Quartile	II,III,IV	0.449	1.000	.018	4	view →
LSCC	OS	Tertile	II,III,IV	0.575	0.899	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX60–HNSC (DFS)

Open the HNSC breakdown →