DDX60

Across TCGA pan-cancer cohorts, DDX60 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DDX60’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DDX60 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX60 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where DDX60 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX60 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.980	<.001	11	view →
KIRC	Male	All	+0.705	<.001	8	view →
LUSC	All	All	−0.693	<.001	7	view →
COAD	Female	All	−2.183	<.001	6	view →
KICH	All	All	−1.035	<.001	6	view →
UCEC	All	All	−0.917	.002	6	view →
BRCA	All	II,III,IV	+0.617	<.001	4	view →
BLCA	All	III,IV	+0.793	.011	3	view →
READ	Female	All	−1.211	.044	2	view →
CHOL	All	All	+1.156	.017	2	view →
ESCA	All	All	+1.496	.025	1	view →
KIRP	All	All	−0.344	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DDX60–HNSC

Open the HNSC breakdown →