DDX60

Across TCGA patient cohorts, DDX60 mutation is significantly associated with the RNA expression of many other genes, with 5,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX60-associated genes across cancer lineages are ZNF367, ORC6, and ECSIT. Each is linked with DDX60 in more than 4 cancer types. Because this analysis shows association rather than direction, both DDX60-to-partner and partner-to-DDX60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by DDX60-low versus DDX60-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX60→partner) and Y-score (partner→DDX60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.493	+1.491	<.001	<.001	3	5
UCEC	ORC6 →	+0.539	+1.595	<.001	<.001	3	5
SKCM	ECSIT →	+0.279	+2.108	.005	<.001	3	5
UCEC	EIF3M →	+0.296	+1.230	.003	.001	3	4
SKCM	GUF1 →	+0.377	+1.820	.001	.002	3	4
SKCM	SUPV3L1 →	+0.306	+1.921	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,136 associations by consensus.

ZNF367 by DDX60 expression — UCEC

Explore this box plot interactively →