DDX6

Across TCGA pan-cancer cohorts, DDX6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX6 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DDX6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DDX6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where DDX6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	1.000	0.868	.002	18	view →
PDAC	DFS	Median	III,IV	0.526	0.266	.010	10	view →
HNSC	DFS	Median	IV	0.515	0.779	.008	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
OV	DFS	Tertile	All	0.819	1.000	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX6–LSCC (DFS)

Open the LSCC breakdown →