DDX6

Across TCGA pan-cancer cohorts, DDX6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DDX6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DDX6 RNA is repressed in tumor relative to normal tissue. In most cancer types DDX6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where DDX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.501	<.001	8	view →
LIHC	Female	II,III,IV	+0.871	<.001	7	view →
HNSC	All	All	+0.423	<.001	7	view →
CHOL	Male	All	+1.771	<.001	5	view →
KICH	All	All	−0.554	.001	4	view →
LUSC	All	All	+0.273	.001	4	view →
LUAD	Male	All	+0.436	<.001	3	view →
UCEC	All	All	−0.453	.013	2	view →
KIRC	All	All	+0.186	.022	2	view →
ESCA	Female	All	+0.673	.016	1	view →
KIRP	Male	All	−0.375	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DDX6–THCA

Open the THCA breakdown →