DDX6

Across TCGA patient cohorts, DDX6 protein abundance is significantly associated with the RNA expression of many other genes, with 20,247 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDX6-associated genes across cancer lineages are PBK, ABCA8, and RFC5. Each is linked with DDX6 in more than 6 cancer types. Because this analysis shows association rather than direction, both DDX6-to-partner and partner-to-DDX6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDX6 versus PBK in UCEC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX6→partner) and Y-score (partner→DDX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+1.362	+0.133	<.001	<.001	3	7
GBM	ABCA8 →	-1.212	-0.222	<.001	<.001	3	7
LSCC	RFC5 →	+0.575	+0.154	<.001	<.001	3	6
LSCC	NAE1 →	+0.507	+0.151	<.001	.001	3	6
GBM	MS4A4E →	-0.870	-0.148	<.001	<.001	3	6
BRCA	FOXM1 →	+1.218	+0.169	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,247 associations by consensus.

DDX6 vs PBK — UCEC

Explore this scatter interactively →