DDX6

Across TCGA patient cohorts, DDX6 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX6-associated genes across cancer lineages are eIF4E, eIF4G, and Gab2. Each is linked with DDX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX6-to-partner and partner-to-DDX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DDX6-low versus DDX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX6→partner) and Y-score (partner→DDX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+3.472	.022	.002	3	1
UCEC	eIF4G →	+0.245	+2.459	.023	.018	3	1
UCEC	Gab2 →	+0.301	+1.440	.015	.024	3	1
UCEC	JNK2 →	+0.167	+2.348	.015	.018	3	1
UCEC	MEK1 →	+0.506	+3.169	<.001	<.001	3	1
UCEC	Notch1 →	+0.183	+3.097	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by DDX6 expression — UCEC

Explore this box plot interactively →