DDX6

Across TCGA cell cohorts, DDX6 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDX6-associated genes across cancer lineages are SEL1L2, R3HDML, and CRISP1. Each is linked with DDX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX6-to-partner and partner-to-DDX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by DDX6-low versus DDX6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX6→partner) and Y-score (partner→DDX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEL1L2 →	+0.073	+4.415	<.001	.007	3	2
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Leukemia	CRISP1 →	+0.193	+5.201	<.001	.006	3	1
BLOOD_Leukemia	HTR3D →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	ZNF729 →	+0.141	+4.922	<.001	.009	3	1
BLOOD_Leukemia	RBMY1D →	+0.180	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SEL1L2 by DDX6 expression — LARGE_INTESTINE

Explore this box plot interactively →