DDX59-AS1

Across TCGA pan-cancer cohorts, DDX59-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DDX59-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DDX59-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX59-AS1 is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

HNSC, COAD, and UCEC are the cancer types where DDX59-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX59-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.611	<.001	11	view →
COAD	All	II,III,IV	+0.373	.001	8	view →
UCEC	All	III,IV	−1.122	.028	4	view →
CHOL	Male	All	+0.933	<.001	4	view →
THCA	Male	All	−0.470	.017	4	view →
BRCA	Female	II,III,IV	+0.338	<.001	4	view →
LIHC	All	All	+0.459	<.001	3	view →
LUSC	All	All	+0.424	<.001	3	view →
BLCA	Male	IV	−0.612	.041	2	view →
KICH	All	All	−0.528	.007	2	view →
LUAD	All	All	+0.302	.004	2	view →
PRAD	All	All	−0.255	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DDX59-AS1–HNSC

Open the HNSC breakdown →