DDX58

Across TCGA patient cohorts, DDX58 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX58-associated genes across cancer lineages are ASNS, Cyclin-B1, and eIF4E. Each is linked with DDX58 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX58-to-partner and partner-to-DDX58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DDX58-low versus DDX58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX58→partner) and Y-score (partner→DDX58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.604	+1.906	<.001	.015	3	2
UCEC	Cyclin-B1 →	+0.829	+2.087	<.001	.005	3	2
UCEC	eIF4E →	+0.168	+3.013	.037	.018	3	2
UCEC	p62 Lck ligand →	+0.452	+3.710	<.001	<.001	3	2
UCEC	P-Cadherin →	-0.141	-2.074	.010	.005	3	2
UCEC	BRCA2 →	-0.124	-2.956	.010	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by DDX58 expression — UCEC

Explore this box plot interactively →