DDX55

Across TCGA pan-cancer cohorts, DDX55 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DDX55 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DDX55 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DDX55 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

LSCC, HNSC, and OV are the cancer types where DDX55 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.906	0.526	<.001	64	view →
HNSC	OS	Median	All	0.296	1.000	.003	40	view →
OV	DFS	Median	All	0.938	0.576	.011	16	view →
CCRCC	OS	Median	II,III,IV	0.622	0.822	.013	16	view →
GBM	OS	Median	All	0.570	0.261	.009	4	view →
LUAD	OS	Median	III,IV	0.230	0.620	.041	2	view →
PDAC	DFS	Tertile	II,III,IV	0.303	0.507	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DDX55–LSCC (DFS)

Open the LSCC breakdown →