DDX54

Across TCGA patient cohorts, DDX54 mutation is significantly associated with the RNA expression of many other genes, with 1,396 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX54-associated genes across cancer lineages are RPL17P50, GCHFR, and SNORD115-45. Each is linked with DDX54 in more than 3 cancer types. Because this analysis shows association rather than direction, both DDX54-to-partner and partner-to-DDX54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P50 grouped by DDX54-low versus DDX54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX54→partner) and Y-score (partner→DDX54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL17P50 →	+0.351	+1.928	.006	.008	3	4
UCEC	GCHFR →	+0.732	+1.815	<.001	.002	3	3
CESC	SNORD115-45 →	+0.289	+4.757	<.001	.004	3	3
SKCM	RNA5SP247 →	+0.633	+3.178	<.001	.003	3	2
COAD	HUNK →	-1.159	-3.459	.004	.005	3	2
COAD	LYG1 →	+0.795	+3.553	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,396 associations by consensus.

RPL17P50 by DDX54 expression — UCEC

Explore this box plot interactively →