DDX54

Across TCGA pan-cancer cohorts, DDX54 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DDX54’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DDX54 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX54 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where DDX54 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX54 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.514	<.001	12	view →
COAD	Female	All	+0.901	<.001	11	view →
HNSC	Male	All	+0.842	<.001	11	view →
KIRP	All	II,III,IV	+0.709	<.001	10	view →
BLCA	All	All	+0.660	<.001	10	view →
STAD	Male	II,III,IV	+1.399	<.001	9	view →
LIHC	Female	II,III,IV	+1.062	<.001	9	view →
LUSC	Male	II,III,IV	+1.093	<.001	7	view →
BRCA	All	All	+0.239	.011	6	view →
CHOL	All	All	+1.727	<.001	5	view →
LUAD	All	III,IV	+0.511	.005	4	view →
READ	All	All	+0.558	.033	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DDX54–KIRC

Open the KIRC breakdown →