DDX54

Across TCGA patient cohorts, DDX54 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX54-associated genes across cancer lineages are STAT3_pY705, ATM, and Caspase-7-cleavedD198. Each is linked with DDX54 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX54-to-partner and partner-to-DDX54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by DDX54-low versus DDX54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX54→partner) and Y-score (partner→DDX54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.374	-1.492	<.001	.027	3	3
UCEC	ATM →	-0.503	-2.102	.001	.016	3	3
UCEC	Caspase-7-cleavedD198 →	+0.516	+1.926	.010	.008	3	3
UCEC	eIF4E →	+0.167	+2.321	.019	.005	3	2
UCEC	Cyclin-E2 →	+0.140	+1.331	.014	.043	3	2
COAD	YAP_pS127 →	-0.430	-3.161	.002	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

STAT3_pY705 by DDX54 expression — UCEC

Explore this box plot interactively →