DDX54

Across TCGA cell cohorts, DDX54 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,901 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDX54-associated GO terms across cancer lineages are Positive regulation of DNA-templated DNA replication, Positive regulation of mitotic cytokinesis, and Regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with DDX54 in more than 15 cancer types. Because this analysis shows association rather than direction, both DDX54-to-partner and partner-to-DDX54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated DNA replication grouped by DDX54-low versus DDX54-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX54→partner) and Y-score (partner→DDX54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA-templated DNA replication →	+0.154	+0.998	<.001	<.001	3	16
BONE	Positive regulation of mitotic cytokinesis →	+0.166	+1.117	.001	<.001	3	15
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.142	+0.780	<.001	<.001	3	15
BONE	DNA replication proofreading →	+0.206	+0.993	<.001	<.001	3	14
LIVER	rRNA 5'-end processing →	+0.195	+0.949	.002	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Signal transduction in response to DNA damage →	+0.087	+0.783	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,901 associations by consensus.

Positive regulation of DNA-templated DNA replication by DDX54 expression — BONE

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