Across TCGA patient cohorts, DDX53 mutation is significantly associated with the RNA expression of many other genes, with 3,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX53-associated genes across cancer lineages are RNU6-697P, TMEM236, and MIR6130. Each is linked with DDX53 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX53-to-partner and partner-to-DDX53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX53→partner) and Y-score (partner→DDX53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-697P →	+0.243	+4.822	<.001	.006	3	3
UCEC	TMEM236 →	+0.135	+2.221	.001	<.001	3	3
BRCA	MIR6130 →	+0.333	+8.471	<.001	.005	3	2
HNSC	RNA5SP433 →	+0.227	+4.736	.008	.007	3	2
HNSC	RNU6-15P →	+0.356	+4.372	.003	.007	3	2
HNSC	MIR520G →	+0.283	+5.008	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,035 associations by consensus.

Exploration

DDX53 survival (RNA) · tumor vs normal (RNA) · all DDX53 data types