Across TCGA pan-cancer cohorts, DDX53 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DDX53’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where DDX53 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX53 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LIHC, BRCA, and LUAD are the cancer types where DDX53 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DDX53 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.464	<.001	6	view →
BRCA	Female	All	+0.058	.018	4	view →
LUAD	All	All	+0.159	.037	2	view →
THCA	Male	II,III,IV	−0.011	.035	2	view →
LUSC	All	II,III,IV	+0.008	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: DDX53 RNA expression & survival · all DDX53 data types