DDX53

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DDX53 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX53-associated genes across cancer lineages are ATM, FoxM1, and mTOR_pS2448. Each is linked with DDX53 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX53-to-partner and partner-to-DDX53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX53→partner) and Y-score (partner→DDX53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECATM →-0.430-1.834.001.00733
UCECFoxM1 →+0.161+1.241.035.01532
UCECmTOR_pS2448 →-0.110-1.202.012.03232
UCECVHL →-0.949-2.369<.001<.00132
UCECCaspase-7-cleavedD198 →+0.543+1.785.001.00732
LUSCAcetyl-a-Tubulin-Lys40 →-1.082-2.990<.001.03631
Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration