Across TCGA cell cohorts, DDX53 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DDX53-associated genes across cancer lineages are CCL16, OR4D2, and C14orf177. Each is linked with DDX53 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX53-to-partner and partner-to-DDX53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX53→partner) and Y-score (partner→DDX53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCL16 →	+0.030	+4.807	<.001	.006	3	1
LUNG_SCLC	OR4D2 →	+0.019	+5.029	<.001	.006	3	1
BLOOD_Leukemia	C14orf177 →	+0.076	+4.922	<.001	.009	3	1
BLOOD_Leukemia	CNGA2 →	+0.099	+5.539	<.001	.003	3	1
BLOOD_Leukemia	GALP →	+0.068	+5.201	<.001	.006	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

DDX53 survival (RNA) · tumor vs normal (RNA) · all DDX53 data types