DDX50

Across TCGA patient cohorts, DDX50 mutation is significantly associated with the RNA expression of many other genes, with 1,209 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX50-associated genes across cancer lineages are RNA5SP34, DUX4L45, and MIR4462. Each is linked with DDX50 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX50-to-partner and partner-to-DDX50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP34 grouped by DDX50-low versus DDX50-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX50→partner) and Y-score (partner→DDX50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP34 →	+0.175	+7.471	.009	.008	3	3
KIRC	DUX4L45 →	+0.069	+5.199	<.001	.007	3	3
BRCA	MIR4462 →	+0.554	+5.045	.001	.009	3	3
BRCA	RNU6-591P →	+0.175	+7.471	<.001	.008	3	3
UCEC	MIR521-1 →	+0.118	+2.827	.002	.002	3	3
SKCM	CDRT8 →	+0.297	+4.296	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,209 associations by consensus.

RNA5SP34 by DDX50 expression — BRCA

Explore this box plot interactively →