DDX5

Across TCGA patient cohorts, DDX5 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX5-associated genes across cancer lineages are VHL, eIF4E, and FASN. Each is linked with DDX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX5-to-partner and partner-to-DDX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by DDX5-low versus DDX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX5→partner) and Y-score (partner→DDX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.032	-3.169	<.001	.018	3	2
UCEC	eIF4E →	+0.205	+2.222	.022	.011	3	1
UCEC	FASN →	+0.646	+3.169	<.001	.018	3	1
UCEC	ACC_pS79 →	+0.371	+2.179	.011	.034	3	1
UCEC	ACC1 →	+0.388	+3.183	.011	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.201	-3.321	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

VHL by DDX5 expression — UCEC

Explore this box plot interactively →