DDX5

Across TCGA pan-cancer cohorts, DDX5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DDX5 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DDX5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DDX5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRC show a favorable association.

BLCA, ACC, and LGG are the cancer types where DDX5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	IV	0.569	0.365	<.001	47	view →
ACC	OS	Median	All	0.673	0.902	<.001	44	view →
LGG	DFS	Median	All	0.295	0.466	<.001	44	view →
UVM	DFS	Quartile	III,IV	0.170	0.900	<.001	27	view →
KIRC	DFS	Quartile	All	0.827	0.676	.025	26	view →
COAD	OS	Median	All	0.873	0.716	.003	26	view →
SKCM	DFS	Quartile	All	0.701	0.517	.004	24	view →
LUSC	DFS	Quartile	III,IV	0.489	1.000	.031	14	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
PAAD	OS	Quartile	All	0.693	0.510	.019	12	view →
LIHC	DFS	Median	III,IV	0.568	0.234	.001	10	view →
THYM	OS	Median	II,III,IV	1.000	0.888	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DDX5–BLCA (DFS)

Open the BLCA breakdown →